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  3. Respiration
  4. Aerobic respiration

Respiration · Process

Aerobic respiration

The reaction that keeps you alive is the photosynthesis equation run backwards, at body temperature, without a flame — and its main product leaves through your mouth without you noticing.

Start here

Someone loses 10 kg of fat. Where does the 10 kg go?

The mass has to go somewhere — matter is not destroyed, as you established in Conservation of mass. Ten kilograms left a person's body, and almost nobody, including most adults, can say by which exit.

Which way did it leave?

At the bench · weigh both sides

The books have to balance

ledger only

The energy transferred is not part of either total.

Glucose respired

A banana

About 25 g of sugar, once the starch in it has been digested.

Goes in

  • Glucose25.0 g
  • Oxygen26.7 g

Comes out

  • Carbon dioxide36.7 g
  • Water15.0 g

Total in 51.7 g

Total out 51.7 g

Energy transferred 390 kJ

The word summary

Photosynthesis, read from right to left.

  • Where

    In the mitochondria

    Almost every cell has them, and cells that work hardest have the most. Not in the lungs, not in the blood — in the cells themselves. The red blood cell is the exception you met in Specialised cells, and having none is why it cannot use the oxygen it carries.

  • When

    Continuously

    There is no off switch. A cell that stops respiring for more than a few minutes dies, which is what makes this the reaction the others depend on.

  • What for

    Every other process

    Movement, keeping warm, building new molecules, active transport, nerve signals. The energy is not stored again — it is spent.

Key fact

Aerobic respiration is glucose + oxygen giving carbon dioxide + water, releasing energy the cell can use. It happens in the mitochondria of almost every cell, continuously, and it is a chemical reaction — not breathing, which is the muscular job that supplies it. The red blood cell is the exception you met in Specialised cells, and it is why it cannot use its own cargo.

Think again

“Respiration is just slow burning.”

The overall equation is the same as burning sugar, and that is where the resemblance stops. Set fire to glucose and it releases everything it has in one uncontrolled rush at several hundred degrees — useless to a cell, and fatal to it. Respiration takes the same molecule apart in a long series of small enzyme-controlled steps at 37 °C, capturing the energy in usable amounts along the way, and it needs no flame and no spark to start. The comparison is worth making precisely because of where it breaks: a fire is a reaction that has escaped control, and a cell is the opposite. The other half of the confusion is the word itself. Respiration is a chemical reaction inside cells; breathing is the muscular job that delivers the oxygen for it, and that distinction is the subject of The gas exchange system, which is the lesson to revisit if it still feels blurred.

“The fat is converted into energy, so the mass disappears.”

Mass cannot turn into energy in a chemical reaction — that is the whole content of Conservation of mass, and biology does not get an exemption. Look at the ledger above: every atom that goes in comes out, and the two totals are identical to the gram. What the glucose or fat supplies is a store of chemical energy, and respiration transfers that energy to the cell while rearranging exactly the same atoms into carbon dioxide and water. The carbon you exhale today was in your breakfast, and before that in a plant, and before that in the air. Weigh the reactants and weigh the products and nothing has gone missing; the only thing that has moved is energy, from a store to where it was needed.

Mastery ladder

Not started yet.

Rungs 3 and 4 you mark yourself.

Rung 1 · The summary

Which is the word summary for aerobic respiration?

Rung 2 · The one that catches people

A person loses 10 kg of fat over a year. Where has almost all of that mass gone?

Rung 3 · Explain the exercise change

When you run, you breathe faster and deeper and your heart beats harder. Explain why, starting from what your muscle cells are doing.

Rung 4 · Take it somewhere new

Germinating peas are sealed in a flask with a thermometer, alongside a second flask of peas that have been boiled and cooled. Both are left overnight. Predict what happens to the temperature, the oxygen and the carbon dioxide in each flask, and explain why the boiled peas are there.

Key note

Glucose + oxygen gives carbon dioxide + water, and energy is transferred to the cell. It happens in the mitochondria of almost every cell, all the time, in small enzyme-controlled steps at body temperature. The red blood cell is the exception, and having no mitochondria is why it cannot use its own cargo. No mass is lost: every atom in the reactants appears in the products, which is why weight lost as fat leaves mostly through the lungs.

Going further

Mitochondria are where the reaction happens, and how many a cell has tells you what it does for a living. A heart muscle cell, contracting every second of your life without a break, is packed with them — by some counts a third of its volume. A skin cell has a fraction of that. Sperm cells carry a spiral of mitochondria wrapped around the base of the tail, powering the only journey they will ever make, and you met that in Gametes and fertilisation. Stranger still, mitochondria have their own small loop of DNA and divide on their own schedule, which is why the accepted explanation is that they began as free-living bacteria absorbed by a larger cell about a billion and a half years ago and never left. Every breath you take supplies oxygen to what were once someone else's cells.

Before this lesson

Connects to

At GCSE this becomes

  • The balanced symbol equation, ATP as the energy currency, and the metabolic rate calculations behind respirometer data.

Where to next

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